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Autocrine Prolactin Associated with Endometrial Cancer Growth, Metastasis, Reduced Sensitivity to Chemotherapy

Researchers have shown that autocrine human prolactin (hPRL) promotes endometrial tumor growth and metastasis, as well as reduces sensitivity to chemotherapy, leading to worse survival outcomes. Based on this association, the investigators also point to a possible therapeutic strategy for endometrial cancer (EC). The results were published recently in Endocrinology. The team, led by Peter...
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Childhood Exposure to Chernobyl Radiation Linked to Increased Risk of Thyroid Nodules

Children who were exposed to radiation following the Chernobyl nuclear accident in April 1986 may have an increased risk of developing thyroid nodules, according to a study recently published in The Journal of Clinical Endocrinology & Metabolism. Researchers led by Elizabeth K. Cahoon, SM, MHS, PhD, of the Radiation Epidemiology Branch, DCEG, at the National...
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Blood Biomarkers Identified in Drug-Resistant Cancer Tumor Cells

While searching for a non-invasive way to detect prostate cancer cells circulating in blood, Duke Cancer Institute researchers have identified some blood markers associated with tumor resistance to two common hormone therapies. In a study published online this month in the journal Clinical Cancer Research, the authors reported that they isolated multiple key gene alterations...
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Case of the Month: Mineral Metabolism & Cancer

endocrine board review This issue highlights the 8th edition of EBR – a mock-exam with more than 240 clinical case questions. Hear expert commentary and read in-depth answer rationales. Available on the online store. A 34-year-old woman presents with nausea, vomiting, mental confusion, and dehydration. Her history is positive for a Wilms tumor as a child and uterine...
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A Pervasive Threat: The Danger of in utero BPA Exposure

breast cancer image A new study presented at ENDO 2016 revealed a possible link between bisphenol A exposure in utero to breast cancer later in life. In the process, the researchers created a new bioassay that can test chemicals much faster than typical animal studies. Almost every single person alive today has detectable amounts of endocrine-disrupting chemicals (EDCs)...
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Cautiously Optimistic: The Future of Pancreatic Cancer Treatments

pancreatic cancer patient As survival rates from pancreatic cancer slowly inch upward, a new drug therapy may offer patients a brighter outlook. For many decades, a diagnosis of pancreatic cancer has been associated with a dismal chance of survival. In 2008, the overall five-year relative survival rate climbed above 5% for the first time — reaching a high...
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Tumor Recall: A Thyroid Cancer Gets Reclassified

thyroid tumor image Literal headlines were made a few months ago when an encapsulated follicular variant of papillary thyroid carcinoma was classified as a non-cancerous thyroid tumor by an international panel of experts. As the debate rages on, all agree on one thing: more studies are needed. In April, the Journal of the American Medical Association Oncology (JAMA Oncology)...